STUDIES ON HUMAN GLYCOGEN
نویسندگان
چکیده
منابع مشابه
Studies on human glycogen. II. Sedimentation in the ultracentrifuge.
Early investigations of the size of glycogen by osmotic pressure measurements indicated molecular weights of 500,000 to 3,500,OOO for this substance (1, 2). Since that time several studies of glycogen have been made in the ultracentrifuge. Bridgman (3) reported that rabbit liver glycogen is inhomogeneous .with the maximum component, having a sedimentation constant of about 70 S and exhibiting a...
متن کاملComparative Studies on Glycogen Phosphorylase
The isolation and crystallization of both forms of glycogen phosphorylase from human skeletal muscle (1) have made possible a detailed study of the properties of these enzymes in comparison with those of rabbit skeletal muscle (2, 3). Phosphorylase b and a from both species have been shown to crystallize under similar conditions and to have similar pH optima, electrophoretic mobilities, sedimen...
متن کاملStructural Studies on Rabbit Muscle Glycogen Synthase
Limited tryptic digestion of either synthase I or D forms resulted in the appearance of a new glucose 6-phosphate-dependent form which was composed of 75,000 molecular weight subunits. Early in tryptic digestion, an intermediate 78,000 subunit was also observed with both forms of the enzyme. The NH,terminal dipeptide sequence of the 75,000 subunit of both forms was the same as that of the origi...
متن کاملStudies on Glycogen Nephrosis in Alloxan-treated Diabetic Rats
Two hundred and seven albino rats were injected subcutaneously with alloxan in doses varying from 140 to 200 mg. per cent per kilo of body weight. Fifty-nine animals which developed hyperglycemia (blood sugar levels above 150 mg. per cent) were observed for periods from 5 days to 32 weeks. Postmortem examination of the kidneys of these diabetic animals revealed glycogen deposition in the loops ...
متن کاملGlycogen in Human Blood
By ROBERT B. Score AND \V. J. S. STILL G LYCOGEN is a major component of platelets and a prominent anatomical feature in electron micrographs.’ It appears as discrete particles of uniform size, although not as diffusely scattered as similar particles in neutrophilic leukocytes.2 The glycogen particle does not exist alone, but has attached to it the enzymes involved in its synthesis and degradat...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1952
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)44815-6